Protease by High-Throughput Docking
The authors report on their discovery of a small molecule that inhibits the NS3 protease of West Nile virus by computer-aided high-throughput docking, and they validate it using thr
Researchers demonstrate that the non-schistosomicidal component in praziquantel is the main contributor to the bitter taste of the drug. They propose using only the pure component of the drug, which would offer the advantage of halving the dose and improving compliance due to removal of the unpleasant taste.
Leishmania-Induced IRAK-1 Inactivation Is Mediated by SHP-1 Interacting with an Evolutionarily Conserved KTIM Motif
Researchers show that upon Leishmania infection, the host protein tyrosine phosphatase SHP-1 is able to rapidly bind to and inactivate a critical kinase. This regulatory binding is mediated by an evolutionarily conserved motif, which is also present in other kinases involved in Toll signaling.
Other PLoS Content
PLoS ONE
Transmission Dynamics of Schistosoma japonicum in the Lakes and Marshlands of China
Identification and Characterization of Novel MicroRNAs from Schistosoma japonicum ee experimental techniques.
The authors report on their discovery of a small molecule that inhibits the NS3 protease of West Nile virus by computer-aided high-throughput docking, and they validate it using thr
Researchers demonstrate that the non-schistosomicidal component in praziquantel is the main contributor to the bitter taste of the drug. They propose using only the pure component of the drug, which would offer the advantage of halving the dose and improving compliance due to removal of the unpleasant taste.
Leishmania-Induced IRAK-1 Inactivation Is Mediated by SHP-1 Interacting with an Evolutionarily Conserved KTIM Motif
Researchers show that upon Leishmania infection, the host protein tyrosine phosphatase SHP-1 is able to rapidly bind to and inactivate a critical kinase. This regulatory binding is mediated by an evolutionarily conserved motif, which is also present in other kinases involved in Toll signaling.
Other PLoS Content
PLoS ONE
Transmission Dynamics of Schistosoma japonicum in the Lakes and Marshlands of China
Identification and Characterization of Novel MicroRNAs from Schistosoma japonicum ee experimental techniques.
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